Sphingolipid Signaling in Metabolic Disorders
نویسندگان
چکیده
منابع مشابه
Sphingolipid signaling mediates iron toxicity.
Iron constitutes a major source of toxicity due to its ability to generate reactive oxygen species that can damage cellular macromolecules. However, the precise mechanism by which exposure to high iron concentrations results in cellular toxicity remains unknown. Here we identify sphingolipid synthesis and signaling as a major mediator of iron toxicity in S. cerevisiae. Inhibition of sphingolipi...
متن کاملTargeting the sphingolipid signaling pathway in stroke.
Stroke welcomes Letters to the Editor and will publish them, if suitable, as space permits. They should not exceed 750 words (including references) and may be subject to editing or abridgment. Please submit letters in duplicate, typed double-spaced. Include a fax number for the corresponding author and a completed copyright transfer agreement form (available online at To the Editor: We congratu...
متن کاملCross-talk between hypoxia and sphingolipid signaling
Hypoxia, e.g., inadequate supply of O2 with respect to needs, is a very common condition that invariantly leads to a variety of responses, which often result into relevant pathophysiological disorders. By sensing the lack of O2 and activating at the molecular level an array of strategies, cells and organisms can however compensate and/or adapt to hypoxia. Of the several mechanisms hitherto prop...
متن کاملSphingolipid abnormalities in psychiatric disorders: a missing link in pathology?
Sphingolipids are biologically active lipids ubiquitously expressed in all vertebrate cells, especially those in the CNS. Aside from their essential roles as structural components of cell membranes, studies over the past two decades have shown that they play vital roles in cellular signaling, cell differentiation and proliferation, apoptosis and inflammation. Given these properties, it is not s...
متن کاملEndocrine and metabolic disorders in β -thalassemia major patients
Background: Thalassemia is the most common hereditary anemia and beta thalassemia major is its most severe form. Endocrine abnormalities in thalassemia major are common disturbing complications that need prompt management. The purpose of this study was to determine the endocrine disorders and bone mineral density in patients with major -thalassemia in Qazvin, Iran. Methods: In this cross- sect...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2012
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2012.06.017